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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站
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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
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来源：长安街知事5月14日，外交部发言人汪文斌主持例行记者会。有记者提问，近日，美国财长耶伦在接受美国媒体采访时再次谈及中国在电动汽车等新能源领域存在所谓“产能过剩”。面对主持人的质疑，耶伦称，“美国会非常明确地针对战略领域进行投资补贴，但我们不希望中国向产能严重过剩的企业提供大量补贴，这只会把我们的企业挤出市场”。拜登将宣布对中国产品加征关税？中方回应
C | 中方对此有何评论？
汪文斌资料图 （图源：外交部网站）汪文斌表示，我们注意到有关的报道。按照美方的逻辑，美国进行补贴就是“至关重要的产业投资”，别国进行补贴就是“令人担忧的不公平竞争”；美国向世界出口有比较优势的产品就是“自由贸易”，别国向世界出口有比较优势的产品就是“产能过剩”。
D | 用中国话来说，就是“只许州官放火，不许百姓点灯”。用美国话来讲，就是“我做了你不能学，我说了你必须做”（Do as I say not as I do）。
说到底，美国就是在打着“产能过剩”的旗号对别国的先进产业进行打压，以“公平竞争”为借口搞保护主义，践踏市场经济原则和国际经贸规则，是赤裸裸的霸凌霸道。
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汪文斌重申，包括电动汽车、锂电池、光伏产品在内的中国新能源产业的快速发展建立在技术持续创新、完善的产供链体系和充分的市场竞争之上，取得的领先地位是比较优势和市场规律共同作用的结果，而非来自所谓的“补贴”。相反，近年来，美方相继签署《芯片与科学法案》《通胀削减法案》，通过数千亿美元的直接和间接补贴，直接干预市场资源配置。美国才是产业补贴的“大户”。
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他指出，补贴补不出产业竞争力，保护也保不出真正强大的企业。中国新能源产业的快速发展符合世界经济实现绿色转型的需要，有利于中国，有利于美国，也有利于世界。
G | “我们奉劝美方，摒弃心口不一的虚伪和双标，不要再重蹈保护主义的覆辙。”
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Published on:17:48:09