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Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

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    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。    　　太原8月24日电 (记者 李庭耀)“能源转型，临汾不仅要有‘煤’的底气，更要有‘绿’的底色。”24日，临汾市委常委、常务副市长胡晓刚在中共山西省委宣传部、山西省人民政府新闻办公室举办的开局起步“十五五”系列主题新闻发布会表示。

二 | 　　“临汾是全省的能源大市，在保障国家能源安全中肩负着重要责任。

三 | ”胡晓刚介绍，“十四五”期间，临汾交出了一份成色不错的“能源答卷”。

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五 | 另一手抓智能绿色开采，加快构建“装备+AI算法+应用”智慧矿山“临汾模式”，到2027年符合条件的生产矿井基本实现智能化，让煤矿从“汗水驱动”向“智能驱动”转变。　　沿黄板块的深层煤层气是临汾巨大的资源宝藏。“十五五”该市将加快大吉煤层气田二期产能建设，推动市域内输气管道互联互通，逐步形成“成环成网、内连外畅”的管网系统，力争2030年产量达到100亿立方米，把非常规天然气打造成临汾新的支柱产业。　　同时，临汾正在重点推动侯马开发区、浮山双新产业园等绿电园区试点建设，创新“绿电+先进制造业”模式，积极招引一批绿电需求大的出口型制造企业落户，把能源优势转化为产业优势。该市把“电动临汾”建设作为能源消费革命的重要突破口，全面开展与宁德时代的战略合作，一体推进换电站网络布局和电池租赁、持车运营、二手车经营服务三大平台建设。　　“目前全市已规划布局41座重卡换电站，年内将逐步形成覆盖主要交通干线的换电网络，让临汾的货车也‘绿’起来，打造山西‘零碳货运走廊’的临汾样板。”胡晓刚说。

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Published on:03:14:22