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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站
一 | Drones zip across city blocks, delivering meals to doorsteps. On factory floors, humanoid robots are put to the test. Streets buzz with electric vehicles, and artificial intelligence (AI) is woven ever deeper into manufacturing, healthcare and urban services. When China hosts the 33rd APEC Economic Leaders' Meeting in Shenzhen this November, delegates will gather in a city that has become one of the country's leading centers for emerging industries. It will be China's third time hosting the event, following Shanghai in 2001 and Beijing in 2014. Adjacent to Hong Kong, Shenzhen in Guangdong Province was one of China's first special economic zones and has evolved over the past four decades into a global hub for innovation and advanced manufacturing. It is home to tech heavyweights such as Huawei, Tencent, BYD, DJI, and UBTECH, along with a vibrant community of startups spanning sectors from AI to new energy. In the first half of 2026, the city's trade with other APEC economies rose 33 percent to 1.98 trillion yuan (about 291.6 billion U.S. dollars), accounting for 68.8 percent of its total foreign trade. Today, Shenzhen offers a window into China's new growth drivers and their potential to create new opportunities across the Asia-Pacific region. LOW-ALTITUDE ECONOMY Official data show that around 70 percent of China's consumer drones and half of its industrial drones are produced in Shenzhen, home to leading manufacturers including DJI. Shenzhen is also a testing ground for commercial drone applications, from logistics and emergency response to power-grid inspection. Food-delivery giant Meituan opened its first drone-delivery route to customers in Shenzhen years ago. By the end of June 2026, its drones were delivering orders from over 1,500 merchants, including KFC, McDonald's and Chinese tea chain Chagee. To support the industry's growth, Shenzhen has built more than 1,200 low-altitude takeoff and landing facilities and opened 310 logistics routes. Cargo drones completed more than 1 million flights in 2025, up 29 percent from a year earlier. Shenzhen has also led the way in regulation. In 2019, it became the first city in China to introduce local legislation specifically for the management of civilian light and micro drones. NEW ENERGY VEHICLES Shenzhen has emerged as one of China's leading hubs for new energy vehicles (NEVs), backed by strong innovation capabilities and one of the country's most complete industrial ecosystems spanning lithium battery materials, energy storage integration and end-use applications. One of the best-known companies benefiting from this ecosystem is BYD, headquartered in Shenzhen. The automaker sold around 2.26 million electric vehicles (EVs) in 2025, surpassing Tesla in global EV sales last year. Its NEVs are now available in 119 countries and regions. The city is also home to more than 1,400 intelligent-driving companies. Shenzhen is investing heavily in charging infrastructure. In 2023, it launched a drive to become a "city of superchargers," and by 2024, supercharging facilities outnumbered conventional petrol stations. So far, it has built more than 1,200 ultra-fast charging stations with charging power of 480 kilowatts or above. ROBOTS AND AI Last year, a robot 6S store, claimed to be the world's first of its kind, opened in Shenzhen and quickly became a local sensation. Shenzhen has fostered a new generation of robotics companies, including UBTECH, Honor and Leju Robot. By the end of 2025, the city was home to 34 listed robotics companies and nine unicorns. The sector expanded rapidly last year. Humanoid robot production surged 83.1 percent year on year to 343,400 units, while the total robotics industrial output value in the city exceeded 240 billion yuan, up over 20 percent year on year. Shenzhen has more than 2,600 major AI companies, with an industry spanning AI chips, algorithm frameworks and foundation models as well as software and hardware applications. AI-enabled smartphones, translation earbuds, smart glasses and smart toys made in Shenzhen are increasingly reaching both domestic and overseas markets. 
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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday.
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels.
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions.
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts.
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times.
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
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