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厦门首批“星火科技馆”出炉 共有77家场馆入选_我的网站

A |     AI摘要      厦门首批77家“星火科技馆”名单出炉，涵盖多领域科普资源。    

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
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B | 该载体旨在盘活社会资源，补充城市科普供给，推动前沿科技向公众开放共享，助力青少年在互动体验中学习科学知识。         记者从市科协获悉，首批厦门市“星火科技馆”名单近日出炉，全市共有77家场馆入选，其中，思明区21家、湖里区10家、集美区12家、海沧区14家、同安区9家、翔安区11家。    据悉，“星火科技馆”是我市打造的特色科普载体。经过自主申报、区级初审、市级复审、现场核查等多轮筛选，首批入选场馆既有厦门大学生物博物馆、厦门科技馆等传统科普阵地，也有重点实验室、企业展厅、农业基地、博物馆以及青少年科技实践场所等，科普内容涵盖人工智能、航空航天、海洋科技、生命健康、气象、农业、生态环保、工业制造、传统文化等多个领域。“星火科技馆”的评选建设，旨在进一步盘活企业、高校和社会场馆资源，补充城市科普阵地供给，让更多前沿科技资源走出实验室、展示厅，更便捷地向社会公众特别是青少年开放共享。    与此同时，不少企业、高校和专业机构的科研、技术资源正通过“星火科技馆”向公众进一步开放。例如，位于海沧区的“数字未来”元宇宙展厅此次入选首批名单。

C | 该展厅此前已获评海沧区科普教育基地，聚焦人工智能大模型、数字人交互等前沿技术，通过数字人互动、海洋文化科普等项目，将较为抽象的数字技术转化为可操作、可体验的科普内容。目前，该展厅已常态化接待中小学生研学团，通过科技大讲堂、项目式体验等方式，让学生在互动操作中理解人工智能、虚拟现实等技术原理，实现“玩中学、做中学”。（厦门日报记者 张珺）。

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Published on:11:26:42